Sickle cell anemia model: brain response to naloxone
Summary:
Analysis of brains of NY1DD transgenic animals treated with naloxone. The NY1DD strain is a model for sickle cell anemia. Naloxone is an opioid antagonist that possesses potent analgesic activity in NY1DD animals. Results provide insight into the mechanism of action of naloxone in this model.
Lunzer MM, Yekkirala A, Hebbel RP, Portoghese PS. Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia. Proc Natl Acad Sci U S A 2007 Apr 3;104(14):6061-5. PMID: 17389363
