TGF-beta effect on normal and tumor cell lines: time course
Summary:
Analysis of normal lung epithelial HPL1D cells and lung adenocarcinoma A549 cells treated with TGF-beta for up to 12 hours. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells but acts as a pro-tumor cytokine by promoting tumour angiogenesis, immune-escape, and metastasis.
GPL3515:
UHN-Toronto 19K single spotted Human EST microarray v7
Citation:
Ranganathan P, Agrawal A, Bhushan R, Chavalmane AK et al. Expression profiling of genes regulated by TGF-beta: differential regulation in normal and tumour cells. BMC Genomics 2007 Apr 11;8:98. PMID: 17425807
