DataSet Record GDS2971: Expression Profiles Data Analysis Tools Sample Subsets
Title: Hemiasterlin analog HTI-286 effect on docetaxel-resistant prostate cancer cell line
Cluster AnalysisGDS2971 Cluster Image
Summary: Analysis of prostate cancer LNCaP cells treated with the chemotherapeutic agent docetaxel or the hemiasterlin analog HTI-286. Like docetaxel, HTI-286 disrupts microtubule dynamics. But unlike docetaxel, HT-286 exhibits reduced multidrug resistance.
Organism: Homo sapiens
Platform: GPL3877: PRHU05-S1-0006 (PC Human Operon v2 21k)
  • Hadaschik BA, Ettinger S, Sowery RD, Zoubeidi A et al. Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin. Int J Cancer 2008 May 15;122(10):2368-76. PMID: 18240145
Reference Series: GSE8325 Sample count: 12
Value type: log2 ratio Series published: 2007/06/29