Cardiac hypertrophy to overt heart failure transition model
Summary:
Analysis of left ventricle (LV) biopsies of hypertrophic hearts from homozygous hypertensive transgenics TGR(mRen-2) 27 (Ren-2) that either progressed to heart failure (HF) or remained compensated. Results provide insight into molecular changes that occur during the hypertrophy-to-HF transition.
GPL1355:
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Citation:
Schroen B, Leenders JJ, van Erk A, Bertrand AT et al. Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy. J Exp Med 2007 May 14;204(5):1227-35. PMID: 17485520
