Analysis of ES cell-derived embryoid bodies (EBs) following transcriptional induction of homeobox transcription factor HOXB4. HOXB4 induction increases production of hematopoietic progenitors within EBs. Results provide insight into molecular mechanisms underlying HOXB4-induced stem cell expansion.
Schiedlmeier B, Santos AC, Ribeiro A, Moncaut N et al. HOXB4's road map to stem cell expansion. Proc Natl Acad Sci U S A 2007 Oct 23;104(43):16952-7. PMID: 17940039