Analysis of nu61 radioresistant tumors following treatment with a mixture of interferons (IFNs) alpha, beta, and gamma. Nu61 tumors derived from the radiosensitive squamous cell carcinoma cell line SCC61. Results provide insight into the role of the IFN signaling pathway in tumor radioresistance.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citations:
Khodarev NN, Beckett M, Labay E, Darga T et al. STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci U S A 2004 Feb 10;101(6):1714-9. PMID: 14755057
Khodarev NN, Minn AJ, Efimova EV, Darga TE et al. Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res 2007 Oct 1;67(19):9214-20. PMID: 17909027
