DataSet Record GDS3432: Expression Profiles Data Analysis Tools Sample Subsets
Title: Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course
Cluster AnalysisGDS3432 Cluster Image
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Summary: Analysis of glucocorticoid receptor alpha (hGRalpha) isoform -A, -B, -C, or -D expressing osteosarcoma cells for up to 24 h after hGRalpha activation with dexomethasone. Cell apoptosis occurred in a GR isoform-selective manner. Results provide insight into the function of each isoform.
Organism: Homo sapiens
Platform: GPL1708: Agilent-012391 Whole Human Genome Oligo Microarray G4112A (Feature Number version)
Citations:
  • Lu NZ, Collins JB, Grissom SF, Cidlowski JA. Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. Mol Cell Biol 2007 Oct;27(20):7143-60. PMID: 17682054
  • Jewell CM, Scoltock AB, Hamel BL, Yudt MR et al. Complex human glucocorticoid receptor dim mutations define glucocorticoid induced apoptotic resistance in bone cells. Mol Endocrinol 2012 Feb;26(2):244-56. PMID: 22174376
Reference Series: GSE6711 Sample count: 60
Value type: transformed count Series published: 2007/12/20