NF-E2-related factor 2 Nrf2 activation effect on the liver
Summary:
Analysis of livers with hepatocyte-specific Keap1 deficiency. Keap1 represses transcription factor NF-E2-related factor 2 (Nrf2) signaling. Amplification of Nrf2 signaling inhibits acute inflammatory liver injury. Results provide insight into the molecular basis of Nrf2-dependent cytoprotection.
Osburn WO, Yates MS, Dolan PD, Chen S et al. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicol Sci 2008 Jul;104(1):218-27. PMID: 18417483
