Aire ectopic expression effect on pancreatic islet beta cells
Summary:
Analysis of pancreatic islet beta cells ectopically expressing Aire. Aire promotes T cell tolerance by inducing the expression of genes encoding peripheral tissue antigens in medullary epithelial cells of the thymus. Results provide insight into the specificity of Aire's effect on transcription.
Guerau-de-Arellano M, Mathis D, Benoist C. Transcriptional impact of Aire varies with cell type. Proc Natl Acad Sci U S A 2008 Sep 16;105(37):14011-6. PMID: 18780794
