Analysis of activated hepatic stellate cells (HSCs) induced to senesce by treatment with a DNA-damaging agent. Upon activation in response to liver damage, HSCs proliferate and produce the extracellular matrix deposited in the fibrotic scar. Senescence of activated HSCs limits liver fibrosis.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Krizhanovsky V, Yon M, Dickins RA, Hearn S et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008 Aug 22;134(4):657-67. PMID: 18724938
