Dendritic cell response to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon receptor activation
Summary:
Analysis of MACS-sorted splenic dendritic cells (DC) from aryl hydrocarbon receptor (AHR) +/+, C57BL6 females after 24hr in vivo treatment with TCDD. The TCDD ligand is an AHR agonist and a potent immunotoxicant. Results provide insight into the consequences of TCDD-induced AHR activation in DCs.
Frericks M, Temchura VV, Majora M, Stutte S et al. Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice. Biol Chem 2006 Sep;387(9):1219-26. PMID: 16972790
