DataSet Record GDS3516: Expression Profiles Data Analysis Tools Sample Subsets
Title: Nodular lymphocyte-predominant Hodgkin lymphoma: lymphocytic and histiocytic cells
Cluster AnalysisGDS3516 Cluster Image
Summary: Analysis of neoplastic lymphocytic and histiocytic cells (L&H) dissected from nodular lymphocyte-predominant Hodgkin lymphoma tumors (NLPHL). L&H cells represent less than 1 percent of cells in NLPHL tumors. Results provide insight into the pathogenesis of NLPHL.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Brune V, Tiacci E, Pfeil I, Döring C et al. Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J Exp Med 2008 Sep 29;205(10):2251-68. PMID: 18794340
  • Giefing M, Winoto-Morbach S, Sosna J, Döring C et al. Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacity. PLoS One 2013;8(12):e84928. PMID: 24376854
  • Weniger MA, Tiacci E, Schneider S, Arnolds J et al. Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells. J Clin Invest 2018 Jul 2;128(7):2996-3007. PMID: 29889102
Reference Series: GSE12453 Sample count: 67
Value type: count Series published: 2008/10/01