Caveolin-3 deficiency effect on virgin mammary glands
Summary:
Analysis of caveolin-3 (Cav-3) deficient mammary glands from virgin females. Cav-3 deficient virgin mammary glands develop lobulo-alveolar hyperplasia, akin to the changes normally observed during pregnancy and lactation. Results provide insight into the molecular basis of this Cav-3 null phenotype.
Sotgia F, Casimiro MC, Bonuccelli G, Liu M et al. Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation. Am J Pathol 2009 Feb;174(2):613-29. PMID: 19164602
