Spinocerebellar ataxia type 1 knock-in model: cerebellum
Summary:
Analysis of cerebella from spinocerebellar ataxia type 1 (SCA1) knockin animals at an early symptomatic disease stage. SCA1 is a neurodegenerative disorder caused by expansion of a glutamine tract in ataxin-1. Results provide insight into the molecular basis of cerebellar pathogenesis in SCA1.
Gatchel JR, Watase K, Thaller C, Carson JP et al. The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A 2008 Jan 29;105(4):1291-6. PMID: 18216249
