PTEN heterozygosity effect on Smoothened-active mouse model
Summary:
Analysis of medulloblastoma (MB) tumors from mice heterozygous for PTEN. SmoA1 +; Pten +/- mice exhibited decreased survival, an increased incidence, and a shorter time to onset of symptoms, compared to SmoA1 +; Pten +/+ mice. Results provide insight into the role of PTEN in the pathogenesis of MB.
Castellino RC, Barwick BG, Schniederjan M, Buss MC et al. Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. PLoS One 2010 May 26;5(5):e10849. PMID: 20520772
