Nrf2-deficient lung response to cigarette smoke: dose response and time course
Summary:
Analysis of lungs from transcription factor Nrf2-deficient animals exposed to cigarette smoke (CS) at various doses and for various lengths of time with or without a subsequent recovery period. Results provide insight into the impact of Nrf2 in acute and subchronic smoking scenarios.
Gebel S, Diehl S, Pype J, Friedrichs B et al. The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes. Toxicol Sci 2010 May;115(1):238-52. PMID: 20133372
