DataSet Record GDS3649: Expression Profiles Data Analysis Tools Sample Subsets
Title: Proinsulin C-peptide and TGF-beta 1 effect on proximal tubular cell line: time course
Cluster AnalysisGDS3649 Cluster Image
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Summary: Analysis of HK2 proximal tubular cells (PTCs) treated with C-peptide, TBF-beta 1, or both agents for 18 or 48 hours. C-peptide alleviates TGF-beta 1-mediated phenotypic and morphological changes in PTCs associated with epithelial-mesenchymal transformation (EMT). EMT contributes to renal fibrosis.
Organism: Homo sapiens
Platform: GPL6884: Illumina HumanWG-6 v3.0 expression beadchip
Citation:
  • Hills CE, Willars GB, Brunskill NJ. Proinsulin C-peptide antagonizes the profibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways. Mol Endocrinol 2010 Apr;24(4):822-31. PMID: 20197308
Reference Series: GSE20247 Sample count: 18
Value type: count Series published: 2010/02/11