Ecotropic viral integration site-1 expression effect on primary bone marrow cells
Summary:
Analysis of C57BL/6 mononuclear bone marrow cells transduced with ecotropic viral integration site-1 (EVI-1). EVI-1 is one of the dominant oncogenes associated with murine and human myeloid leukemia. Results provide insight into the mechanistic basis of Evi1-mediated leukemogenesis.
Yoshimi A, Goyama S, Watanabe-Okochi N, Yoshiki Y et al. Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. Blood 2011 Mar 31;117(13):3617-28. PMID: 21289308
