Transactive response DNA-binding protein (TDP-43) knockdown effect on embryonic kidney cells
Summary:
Analysis of HEK293E cells depleted of transactive response DNA-binding protein (TDP-43). Inclusions of TDP-43 are hallmarks of frontotemporal dementia and amyotrophic lateral sclerosis (ALS). Results provide insight into the molecular basis of TDP-43 misfunction in neurodegenerative diseases.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Fiesel FC, Voigt A, Weber SS, Van den Haute C et al. Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO J 2010 Jan 6;29(1):209-21. PMID: 19910924
