Receptor for AGE (RAGE) deletion effect on ApoE null mice: aorta
Summary:
Analysis of aortas of nondiabetic and diabetic ApoE-null mice expressing or lacking the multiligand receptor for advanced glycation end products (RAGE). RAGE contributes to atherosclerosis in ApoE-null mice. Results provide insight into molecular mechanisms by which RAGE accelerates atherosclerosis.
Bu DX, Rai V, Shen X, Rosario R et al. Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice. Circ Res 2010 Apr 2;106(6):1040-51. PMID: 20133903
