Analysis of umbilical vein endothelial cells (ECs) transfected with MEK5D, a constitutively active mutant kinase, to activate Erk5. The MEK5/Erk5 MAPK pathway is activated by laminar shear stress in ECs. Results provide insight into the role of the MEK5/Erk5 pathway in endothelial function.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Ohnesorge N, Viemann D, Schmidt N, Czymai T et al. Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J Biol Chem 2010 Aug 20;285(34):26199-210. PMID: 20551324
