In vivo glucocorticoid effect on non-leukemic peripheral blood lymphocytes
Summary:
Analysis of mononuclear cells from non-leukemic individuals (1 healthy/3 epileptic) up to 24 hr after glucocorticoid (GC) injection. GCs induce apoptosis and are used to treat lymphoid malignancies. Results provide insight into molecular mechanisms responsible for the anti-leukemic GC effects.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Carlet M, Janjetovic K, Rainer J, Schmidt S et al. Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells. BMC Cancer 2010 Nov 23;10:638. PMID: 21092265
