DataSet Record GDS3884: Expression Profiles Data Analysis Tools Sample Subsets
Title: Type 2 diabetic and insulin-resistant but normoglycemic cohorts: skeletal muscle
Cluster AnalysisGDS3884 Cluster Image
Summary: Analysis of quadriceps muscle from type 2 diabetes (T2D) patients and from normoglycemic but insulin-resistant subjects with a parental family history of T2D. Insulin resistance in skeletal muscle is a key phenotype of T2D. Results provide insight into the molecular basis of this insulin resistance.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Jin W, Goldfine AB, Boes T, Henry RR et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest 2011 Mar;121(3):918-29. PMID: 21393865
  • Lerin C, Goldfine AB, Boes T, Liu M et al. Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. Mol Metab 2016 Oct;5(10):926-936. PMID: 27689005
Reference Series: GSE25462 Sample count: 50
Value type: count Series published: 2011/03/01