Hematopoietic CD34+ cells exposed in vitro to dioxin
Summary:
Analysis of hematopoietic progenitor CD34+ cells from 5 healthy donors (3 paired samples) before and after in vitro 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. Results provide insight into the molecular pathways of TCDD-induced hematopoietic progenitor cell impairment in bone marrow.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Fracchiolla NS, Todoerti K, Bertazzi PA, Servida F et al. Dioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects. Toxicology 2011 Apr 28;283(1):18-23. PMID: 21296121
