Directed differentiation of embryonic stem cells and induced pluripotent stem cells
Summary:
Analysis of ES cells and iPS cells before (day 0) and after (day 5) endodermal differentiation. E8.25 embryonic definitive endoderm (DE) was also examined. Results provide insight into the relative equivalency of DE derived from ES/iPS cells in vitro and authentic DE from embryos in vivo.
Christodoulou C, Longmire TA, Shen SS, Bourdon A et al. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. J Clin Invest 2011 Jun;121(6):2313-25. PMID: 21537085
