Polyubiquitin knockout effect on testis: time course
Summary:
Analysis of testes from Ubb knockouts at 7 to 28 days postpartum (dpp). Loss of Ubb leads to infertility, with germ cells arrested at meiotic prophase I. Results provide insight into molecular mechanisms underlying mammalian fertility.
Sinnar SA, Small CL, Evanoff RM, Reinholdt LG et al. Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb. Mol Reprod Dev 2011 Jun;78(6):415-25. PMID: 21542049