Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.
GPL341:
[RAE230A] Affymetrix Rat Expression 230A Array
Citation:
Kadish I, Thibault O, Blalock EM, Chen KC et al. Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci 2009 Feb 11;29(6):1805-16. PMID: 19211887
