DataSet Record GDS3915: Expression Profiles Data Analysis Tools Sample Subsets
Title: Aging and cognitive decline: hippocampus
Cluster AnalysisGDS3915 Cluster Image
Summary: Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.
Organism: Rattus norvegicus
Platform: GPL341: [RAE230A] Affymetrix Rat Expression 230A Array
  • Kadish I, Thibault O, Blalock EM, Chen KC et al. Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci 2009 Feb 11;29(6):1805-16. PMID: 19211887
Reference Series: GSE9990 Sample count: 49
Value type: count Series published: 2009/01/18