Cdx2 and Gata3 overexpression effect on R1 embryonic stem cell line
Summary:
Analysis of R1 embryonic stem (ES) cells overexpressing transcription factor Cdx2 or Gata3 and cultured under trophoblast stem (TS) cell derivation conditions. Gata3-expressing Cdx2-null ES cells also examined. Results provide insight into the roles of Gata3 and Cdx2 in trophoblast development.
Ralston A, Cox BJ, Nishioka N, Sasaki H et al. Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development 2010 Feb;137(3):395-403. PMID: 20081188
