DataSet Record GDS3976: Expression Profiles Data Analysis Tools Sample Subsets
Title: Premature Hematopoietic Aging model: bone marrow hematopoietic stem cells
Cluster AnalysisGDS3976 Cluster Image
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Summary: Analysis of hematopoietic stem cells (HSCs) from mid-aged mutator females that express a proofreading-defective form of the mitochondrial DNA polymerase gamma (POLG). Results provide insight into the molecular mechanisms underlying multiple aspects of aging accelerated in the mutator model.
Organism: Mus musculus
Platform: GPL1261: [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Citations:
  • Norddahl GL, Pronk CJ, Wahlestedt M, Sten G et al. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 2011 May 6;8(5):499-510. PMID: 21549326
  • Wahlestedt M, Erlandsson E, Kristiansen T, Lu R et al. Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate. Nat Commun 2017 Feb 22;8:14533. PMID: 28224997
Reference Series: GSE27686 Sample count: 16
Value type: count Series published: 2011/05/06