Segmented filamentous bacteria gut colonization effect on nonobese diabetic mice: T cells
Summary:
Analysis of T cells from spleen and gut of SFB-positive NOD mice. SFB induces a robust T-helper cell type 17 population in small-intestinal lamina propria (SI-LP). Results provide insight into molecular mechanisms underlying the strong cosegregation of SFB positivity and protection from diabetes.
Kriegel MA, Sefik E, Hill JA, Wu HJ et al. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A 2011 Jul 12;108(28):11548-53. PMID: 21709219
