Transient hyperglycemia effect on transgenic diabetic aorta: time course
Summary:
Analysis of aorta of pIns-c-MycERTAM females treated with tamoxifen (c-Myc 'ON'; rendered transiently hypo- and then hyperglycemic) then not treated (c-Myc 'OFF'; recovery from hyperglycemia). Results provide insight into molecular effects on artery caused by short-term exposure to hyperglycemia.
Zervou S, Wang YF, Laiho A, Gyenesei A et al. Short-term hyperglycaemia causes non-reversible changes in arterial gene expression in a fully 'switchable' in vivo mouse model of diabetes. Diabetologia 2010 Dec;53(12):2676-87. PMID: 20844862
