CD4+CD25+ regulatory T cells from spleen of NOD model of type 1 diabetes
Summary:
Analysis of sorted, splenic CD4+CD25+ regulatory T (Treg) and conventional CD4+CD25- T cells (Tconv) from 6 to 7-week-old, nonobese diabetic NOD mice. FoxP3+Tregs protect against autoimmune T1D. Results provide insight into molecular mechanisms underlying the immune dysregulation in this T1D model.
D'Alise AM, Auyeung V, Feuerer M, Nishio J et al. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A 2008 Dec 16;105(50):19857-62. PMID: 19073938
