Postmortem temporal cortex from Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort: astrocytes
Summary:
Analysis of GFAP+ astrocytes representing different Braak stages and ApoE genotypes, in post-mortem temporal cortex samples. Astrocytes synthesize ApoE, which is involved in the astrocytic clearance of aggregated β-amyloid plaques. Results provide insight into role of ApoE in Alzheimer's pathology.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Simpson JE, Ince PG, Shaw PJ, Heath PR et al. Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiol Aging 2011 Oct;32(10):1795-807. PMID: 21705112
