Proteasomal inhibitor lactacystin effect on cortical neurons in vitro: time course (MG_U74Av2)
Summary:
Analysis of cultured cortical neurons treated with 1uM lactacystin for up to 48 hr. Lactacystin induces neuronal apoptosis. Results provide insight into molecular mechanisms underlying proteasomal inhibition-induced neuronal death.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Choy MS, Chen MJ, Manikandan J, Peng ZF et al. Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin. J Cell Physiol 2011 Feb;226(2):494-510. PMID: 20683911
