Analysis of 2 iPSC clones with presenilin 2 (PS2) mutation N141, established by retroviral transduction of fibroblasts from a Familial Alzheimer’s disease (FAD) patient. PS2 mutations are causative factors for autosomal-dominant early-onset FAD. Results provide insight into molecular basis of FAD.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Yagi T, Ito D, Okada Y, Akamatsu W et al. Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum Mol Genet 2011 Dec 1;20(23):4530-9. PMID: 21900357
