DNA methyltransferase triple knockout nuclear transfer-trophoblastic stem cells
Summary:
Analysis of Dnmt1/3a/3b-TKO ntTS cells, wildtype ntTS cells, and cell types representing the three blastocyst-derived lineages: epiblast (ES cells), trophectoderm (TS cells), and primitive endoderm (XEN cells, PE cells). Results provide insight into role of DNA methylation in early embryogenesis.
Sakaue M, Ohta H, Kumaki Y, Oda M et al. DNA methylation is dispensable for the growth and survival of the extraembryonic lineages. Curr Biol 2010 Aug 24;20(16):1452-7. PMID: 20637626
