Notch1 promoter deletion effect on Ikaros-deficient model of T-cell acute lymphoblastic leukemia: thymic lymphoma
Summary:
Analysis of thymic tumors from Ikaros-deficient (IkL/L) mice with a Notch promoter/exon1 deletion. The deletion of Notch1 promoter results in oncogenic activation of Notch1 and significantly accelerates leukemogenesis. Results provide insight into role of Notch activation in pathogenesis of T-ALL.
Jeannet R, Mastio J, Macias-Garcia A, Oravecz A et al. Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Blood 2010 Dec 16;116(25):5443-54. PMID: 20829372
