DataSet Record GDS4177: Expression Profiles Data Analysis Tools Sample Subsets
Title: Imatinib treatment of chronic myeloid leukemia cell lines: KU-812, KCL-22 and JURL-MK1
Cluster AnalysisGDS4177 Cluster Image
Summary: Analysis of CML cell lines (KU-812, KCL-22, and JURL-MK1) treated with tyrosine kinase inhibitor imatinib. Imatinib inhibits oncogenic BCR-ABL1, a tyrosine kinase present in most CML patients. Results provide insight into molecular mechanisms underlying imatinib inhibition of CML.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Duy C, Hurtz C, Shojaee S, Cerchietti L et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 2011 May 19;473(7347):384-8. PMID: 21593872
  • Hurtz C, Hatzi K, Cerchietti L, Braig M et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med 2011 Oct 24;208(11):2163-74. PMID: 21911423
Reference Series: GSE24493 Sample count: 6
Value type: count Series published: 2010/10/10