DataSet Record GDS4188: Expression Profiles Data Analysis Tools Sample Subsets
Title: CD3+ T cell response to stimulation with CD3/CD28 or nitric oxide
Cluster AnalysisGDS4188 Cluster Image
Summary: Analysis of healthy T cells stimulated with CD3/CD28 (a Ca2+ fluxing inducer) or NO (a key trigger of mitochondrial hyperpolarization (MHP)). Enhanced Ca2+ fluxing and MHP underlie aberrant T-cell activation in SLE. Results provide insight into the molecular basis of T cell dysfunction in lupus.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Fernandez DR, Telarico T, Bonilla E, Li Q et al. Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol 2009 Feb 15;182(4):2063-73. PMID: 19201859
Reference Series: GSE13887 Sample count: 12
Value type: count Series published: 2009/02/20