NZM2410-derived lupus susceptibility locus Sle2c1: peritoneal cavity B cells
Summary:
Analysis of peritoneal cavity B cells (B1a) and splenic B (sB) cells from B6.Sle2c1 mice. Sle2 induces expansion of the B1a cell compartment, a B cell defect consistently associated with lupus. Results provide insight into molecular mechanisms underlying susceptibility to lupus in the NZM2410 model.
Xu Z, Potula HH, Vallurupalli A, Perry D et al. Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1. J Immunol 2011 Jun 15;186(12):6673-82. PMID: 21543644
