Wild-type embryonic stem cell rescue of mdx model of Duchenne muscular dystrophy: skeletal muscle
Summary:
Analysis of pectoralis muscle from 4 month-old, wildtype/mdx chimeric males. Chimeras were created by injecting WT ESCs into mdx mutant blastocysts; injected blastocysts developed in the uterus of pseudopregnant females. Results provide insight into molecular basis of WT ESC rescue of mdx mice.
Stillwell E, Vitale J, Zhao Q, Beck A et al. Blastocyst injection of wild type embryonic stem cells induces global corrections in mdx mice. PLoS One 2009;4(3):e4759. PMID: 19277212
