Growth factor independence 1 knockout effect on LSK hematopoietic stem bone marrow cells
Summary:
Analysis of Lin-Sca1+ckit+Flt3- (LSKFlt3-) hematopoietic stem cells (HSC) depleted of growth factor independence 1 (Gfi1). Transcriptional repressor Gfi1 restricts HSC proliferation and is essential to self-renewal. Results provide insight into molecular mechanisms underlying Gfi1 effects in HSCs.
Khandanpour C, Kosan C, Gaudreau MC, Dührsen U et al. Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells 2011 Feb;29(2):376-85. PMID: 21732494
