Transcription factor c-JUN knockout effect on B lymphoid cells
Summary:
Analysis of B lymphoid cells depleted of activating protein 1 (AP-1) transcription factor c-JUN. c-JUN is involved in BCR-ABL oncogene-induced transformation and leukemogenesis. Results provide insight into the molecular mechanisms underlying c-JUN modulation of leukemogenesis.
Kollmann K, Heller G, Ott RG, Scheicher R et al. c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood 2011 Apr 14;117(15):4065-75. PMID: 21300982