Anti-CD47 antibody dimer MABL (S-S diabody) effect on leukemia cell line: time course
Summary:
Temporal analysis of MOLT-4 leukemia cells treated with 10 ug/mL anti-CD47 dimer MABL (S-S diabody). Cell surface antigen CD47 ligation induces apoptosis in B-chronic lymphocytic leukemia. Results provide insight into the molecular mechanism of CD47-mediated apoptosis in lymphoid malignant cells.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Sagawa M, Shimizu T, Fukushima N, Kinoshita Y et al. A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1α pathway. Cancer Sci 2011 Jun;102(6):1208-15. PMID: 21401803
