Pathogenic Simian Immunodeficiency Virus infection in Rhesus macaques: colorectal tissue
Summary:
Analysis of colorectal biopsies from SIV-infected Rhesus macaques (RM) and Sooty mangabeys (SM). Unlike AIDS-susceptible RMs, natural hosts such as SMs do not progress to AIDS. Results provide insight into molecular basis of immune activation following pathogenic immunodeficiency virus infections.
Kwa S, Kannanganat S, Nigam P, Siddiqui M et al. Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques. Blood 2011 Sep 8;118(10):2763-73. PMID: 21693759
