Transgenic model Tg26 of HIV-Associated Nephropathy: kidney cortex
Summary:
Analysis of kidney cortices from HIV-1 transgenic, FVB/N males and females (Tg26). Tg26 models the renal pathologic changes observed in human disease and is used to study HIV-associated nephropathy (HIVAN) pathogenesis. Results provide insight into the molecular mechanisms underlying HIVAN.
Jin Y, Ratnam K, Chuang PY, Fan Y et al. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nat Med 2012 Mar 11;18(4):580-8. PMID: 22406746
