Balanced and unbalanced chromosomal translocations: lymphoblastoid cell lines
Summary:
Analysis of lymphoblastoid cell lines established from individuals with the t(11;22)(q23;q11)-balanced translocation (carriers) or the +der(22)t(11;22)(q23;q11) karyotype (Emanuel syndrome patients). Results provide insight into the effect of balanced chromosomal rearrangements on the transcriptome.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Harewood L, Schütz F, Boyle S, Perry P et al. The effect of translocation-induced nuclear reorganization on gene expression. Genome Res 2010 May;20(5):554-64. PMID: 20212020
