DataSet Record GDS4273: Expression Profiles Data Analysis Tools Sample Subsets
Title: Pediatric age-specific host response to septic shock: whole blood
Cluster AnalysisGDS4273 Cluster Image
Summary: Analysis of whole blood from children (up to 10 years old) within 24hrs of PICU admission for septic shock. Sepsis therapies useful in adults and older children may have little effect in immunologically immature younger patients. Results provide insight into age-specific host response to sepsis.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Wynn JL, Cvijanovich NZ, Allen GL, Thomas NJ et al. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med 2011;17(11-12):1146-56. PMID: 21738952
  • Grunwell JR, Weiss SL, Cvijanovich NZ, Allen GL et al. Differential expression of the Nrf2-linked genes in pediatric septic shock. Crit Care 2015 Sep 17;19:327. PMID: 26376786
  • Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ et al. Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock. Am J Respir Crit Care Med 2014 Apr 15;189(8):940-6. PMID: 24650276
Reference Series: GSE26378 Sample count: 103
Value type: transformed count Series published: 2011/01/13