Analysis of gonadotrope/null cell tumors and normal pituitaries from autopsy samples. Pituitary gonadotrope tumors cause significant morbidity, hormonal deficits, and are more common in men. Results provide insight into molecular mechanisms involved in pituitary tumorigenesis and progression.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Michaelis KA, Knox AJ, Xu M, Kiseljak-Vassiliades K et al. Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors. Endocrinology 2011 Oct;152(10):3603-13. PMID: 21810943
