BCL6 corepressor somatic mutation in acute myeloid leukemia with normal karyotype: Ficoll-enriched mononuclear cells
Summary:
Analysis of mononuclear cells from normal karyotype, acute myeloid leukemia (CN-AML) patients with BCL6 corepressor (BCOR) mutation. CN-AML BCOR mutations are associated with oculo-facio-cardiodental genetic syndrome and poor outcome. Results provide insight into role of BCOR in CN-AML pathogenesis.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Grossmann V, Tiacci E, Holmes AB, Kohlmann A et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 2011 Dec 1;118(23):6153-63. PMID: 22012066
